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托福听力练习-科学美国人60秒:止痛剂变为抗生素

2017-02-11 16:19:00来源:科学美国人60秒

点击查看>>科学美国人60秒音频:止痛剂变为抗生素

  科学美国人60秒中英文翻译:止痛剂变为抗生素

  科学美国人60秒英文文本

  The pain-relieving effects of drugs like ibuprofen are well known.

  But ibuprofen and its relatives, known as nonsteroidal anti-inflammatory drugs, may someday have another use—as antibiotics.

  Researchers tested three anti-inflammatory drugs: bromfenac, used in eye drops, and carprofen and vedaprofen, both for treating conditions like arthritis in dogs.

  Investigators found that all three drugs bind to something called the "DNA clamp" in bacteria.

  That clamp is essential to repairing and replicating DNA.

  By jamming it, the painkillers can actually kill live E.coli—in a test tube, at least.

  The findings appear in the journal Chemistry & Biology.

  Study author Aaron Oakley, of Australia's University of Wollongong, says we still need clinical trials to tell if this trick holds true in humans.

  But this study is a first step.

  "I guess it alerts a lot of clinicians to the fact that some of the nonsteroidal anti-inflammatories that they're using may have this off-target effect."

  And it gives drug developers—like Oakley and his colleagues—a whole new way to attack antibiotic-resistant bacteria.

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